Newsroom, your daily review

Keep up with the latest in the tableting community!


Announcement

MySTYL'One

Nov. 30, 2022

Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering


In this paper you will find how to utilize a particle engineering strategy to improve the manufacturability of a cohesive and poorly compactable API at high drug loading for direct compression of mini-tablets. The study is available in the PAPERS section.

Find others papers here and learn about

  • Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions
  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • Scaling Tableting Processes from Compaction Simulator to Rotary Presses—Mind the Sub-Processes

#STYL'One #direct compression #wet milling #tabletability #particle engineering #mini-tablets #flowability

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Announcement

MySTYL'One

Nov. 29, 2022

Direct Compression of Probiotic Tablets with PROSOLV® EASYtab Nutra


MySTYL'One user exclusive!

This new bulletin available details a study showing that PROSOLV® EASYtab Nutra is considerably better suited for direct compression of probiotic tablets.

#direct compression #prosolv #easytab #probiotic

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Announcement

MySTYL'One

Nov. 24, 2022

Tableting Performance of Maize and Potato Starches Used in Combination as Binder/Disintegrant in Metronidazole Tablet Formulation


In this paper you will find how to characterize the tableting performance of maize and potato starches, when used in combination either as a disintegrant or binder in solid dosage form development. The study is available in the PAPERS section.

Find others papers here and learn about

  • Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants
  • Evaluation of Tableting Performance of Poly (ethylene oxide) in Abuse-Deterrent Formulat...

In this paper you will find how to characterize the tableting performance of maize and potato starches, when used in combination either as a disintegrant or binder in solid dosage form development. The study is available in the PAPERS section.

Find others papers here and learn about

  • Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants
  • Evaluation of Tableting Performance of Poly (ethylene oxide) in Abuse-Deterrent Formulations using Compaction Simulation Studies
  • Polyglycerol Esters of Fatty Acids as Safe and Stable Matrix Forming Tableting Excipients: A Structure-Function Analysis

#STYL'One #direct compression #wet milling #tabletability #mini-tablets #flowability

Video

Thermofisher Scientific

Nov. 23, 2022

Material matters: Material Science, Process Simulation and Modeling for Oral Solid Dosage Forms

With the ever-growing pressure to get new therapies to patients faster, predictive modeling and simulation tools are increasingly recognized as critical enabling technologies for accelerating drug product development. In the development of oral solid dosage forms, predictive modeling and simulation tools of the manufacturing processes can enhance process understanding, save on API supply, improve product quality, and reduce or eliminate many of the bottlenecks associated with empirical method...

With the ever-growing pressure to get new therapies to patients faster, predictive modeling and simulation tools are increasingly recognized as critical enabling technologies for accelerating drug product development. In the development of oral solid dosage forms, predictive modeling and simulation tools of the manufacturing processes can enhance process understanding, save on API supply, improve product quality, and reduce or eliminate many of the bottlenecks associated with empirical methods.

Each active pharmaceutical ingredient (API) has its own set of unique physical and chemical properties that can affect the success of product formulations and manufacturing routes. On account of this, the manufacturing process for solid dosage forms need to be thoroughly understood. Determining robust formulations and processes for a given compound requires a deep understanding of material science and powder behavior.

#R&D #STYL'One evo #Powder compaction #science lab #Material science

Announcement

MySTYL'One

Nov. 22, 2022

Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering


In this paper you will find how to utilize a particle engineering strategy to improve the manufacturability of a cohesive and poorly compactable API at high drug loading for direct compression of mini-tablets. The study is available in the PAPERS section.

Find others papers here and learn about

  • Manufacturing of mini-tablets. Focus and impact of the tooling systems
  • Using a Model-based Material Sparing Approach for Formulation and Process Development of a Roller Compacted Drug Product
  • Effect of the...

In this paper you will find how to utilize a particle engineering strategy to improve the manufacturability of a cohesive and poorly compactable API at high drug loading for direct compression of mini-tablets. The study is available in the PAPERS section.

Find others papers here and learn about

  • Manufacturing of mini-tablets. Focus and impact of the tooling systems
  • Using a Model-based Material Sparing Approach for Formulation and Process Development of a Roller Compacted Drug Product
  • Effect of the compaction parameters on the final structure and properties of a press-coated tablet (Tab-in-Tab): Experimental and numerical study of the influence of core and shell dimensions

#STYL'One #direct compression #wet milling #tabletability #mini-tablets #flowability

Feature article

Pharmaceutical Technology

Nov. 22, 2022

On the trail of solubility

Innovative, Copenhagen-based startup Zerion Pharma utilizes the equipment and know-how of the MEDELPHARM INNOVATION CENTER (called “Science Lab” in France) for product development purposes. KORSCH:MAGAZINE spoke with Zerion Pharma’s scientific director, Søren Vinter Søgaard, and the company’s co-founder and CSO, Korbinian Löbmann.

#STYL'One evo #expertise #zerion pharma #R&D #MEDELPHARM #technology #science lab

Announcement

MySTYL'One

Nov. 20, 2022

Varied Bulk Powder Properties of Micro-Sized API within Size Specifications as a Result of Particle Engineering Methods


In this paper you will find how to highlights the measurable impact of processing route on API properties and the importance of selecting a suitable processing route for preparing fine particles with optimal properties and performance. The study is available in the PAPERS section.

Find others papers here and learn about

  • Effect of Polymers and Drug Loadings on the Performance of Itraconazole Spray- dried Dispersions (SDDs)
  • Direct Compression Tablet Formulation of Celecoxib Enabled with a Pharmace...

In this paper you will find how to highlights the measurable impact of processing route on API properties and the importance of selecting a suitable processing route for preparing fine particles with optimal properties and performance. The study is available in the PAPERS section.

Find others papers here and learn about

  • Effect of Polymers and Drug Loadings on the Performance of Itraconazole Spray- dried Dispersions (SDDs)
  • Direct Compression Tablet Formulation of Celecoxib Enabled with a Pharmaceutical Solvate
  • The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of itraconazole-HPMCAS spray dried dispersions

#contact angle #particle size #STYL'One #bulk properties #surface anisotropy

Feature article

Pharmaceutical Technology

Nov. 18, 2022

A collaborative partner for powder processing R&D in universities and beyond

Powder processing research and development (R&D) has its challenges, with experienced scientists and students alike coming across hurdles even when they have the best equipment. Rather than struggling alone, the key is collaboration.

#R&D #troubleshooting #MEDELPHARM #expertise

Feature article

Adare Pharma Solutions

Oct. 20, 2022

Taste Masking 101: Optimize Taste and Improve Patient Outcomes

Taste masking, combined with swallowability and palatability, are integral considerations for oral drug formulations; ensuring both as part of a drug product’s final formulation can serve to increase patient acceptability and adherence to the therapy, which in turn can bolster regulatory acceptance and commercial potential.

#drug formulation #pediatric drug development #dosage form

Feature article

Adare Pharma Solutions

Oct. 6, 2022

Formulation Considerations for Pediatric Populations: Finding the Right Dosage Form for Better Adherence

To address the challenges of pediatric formulations, specialized technology platforms are often needed to provide ease of application and improve patient outcomes.

#drug formulation #pediatric drug development #dosage form

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