Newsroom, your daily review

Keep up with the latest in the tableting community!


Announcement

MySTYL'One

Oct. 3, 2022

Studies on the influence of high-shear granulation process on the compressibility of microcrystalline cellulose


In this study, the effect of the high-shear granulation process on the compressibility of MCC was characterized by plotting the compression characteristics curve, as well as the mechanism of the effect from the perspectives of mechanical properties, powder properties. The study is available in the PAPERS section.

Find others papers here and learn about

  • Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants
  • Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose
  • Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

#powder property #high-shear granulation #compressibility #mechanical properties

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Announcement

MySTYL'One

Sept. 26, 2022

The Performance Of PROSOLV EASYtab SP In Four Medium-Dose, Direct Compression Formulations With Morphologically Challenging Model APIs


MySTYL'One user exclusive!

This new bulletin available details a study on the performance of PROSOLV EASYtab SP by testing it in four DC formulations with different model APIs.

#API #prosolv #excipient composite #dry blends #direct compression

Got questions? Ask your peers!

Announcement

MySTYL'One

Sept. 22, 2022

The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation


In this paper, the information on excipients physical and chemical instability and compatibility with the active pharmaceutical component in solid oral dosage forms during various drug manufacturing procedures is reviewed. The study is available in the PAPERS section.

Find others papers here and learn about

  • A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants
  • Development of an Automated Microscale Manufacturing System for Oral Solid Dosage Forms
  • A generalized image analytical algorithm for investigating tablet disintegration

#oral solid dosage forms #pills #excipients #capsules #tablet #powder

Feature article

Korsch.com

Sept. 15, 2022

Everything starts with an understanding of the materials


On this article you will find how simulators and software solutions can provide valuable product development support when appropriate raw materials need to be selected.

#API #dosage form #raw materials #direct tableting

Announcement

MySTYL'One

Sept. 13, 2022

The effect of granules characters on mechanical properties of press-coated tablets: A comparative study


The present work investigate the correlation between critical granules characters (including particle size, surface roughness, and apparent porosity) and mechanical properties of press-coated tablets. The study is available in the PAPERS section.

Find others papers here and learn about

  • Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants
  • Development and pharmaceutical performance of a novel co-processed excipient of alginic acid and microcrystalline cellulose
  • Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

#mechanical properties #press-coating #Porosity #granules characters #surface roughness #interlayer adhesion forces

Announcement

MySTYL'One

July 26, 2022

Replay: "Fundamental Investigations on Bilayer Tablets"

Replay of the webinar 

--> MySTYL'One members: access the webinar page for the full replay

--> Not a member, but would like to view the video? Fill out online request form: https://form.jotform.com/222024289539055 

Access the replay of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" with thanks to the links above.

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig &am...

Replay of the webinar 

--> MySTYL'One members: access the webinar page for the full replay

--> Not a member, but would like to view the video? Fill out online request form: https://form.jotform.com/222024289539055 

Access the replay of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" with thanks to the links above.

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig & Senior Scientist, Fraunhofer IST
*Bruno Leclercq, Science Lab Head and Business Development Manager, MEDELPHARM

Webinar agenda: 

  • Measurement of interfacial adhesion strength 
  • Influence of material deformation behaviour & impact of process parameters and tablet geometry
  • Detection of signs of internal stresses before delamination 
  • Demonstration of multilayer tablet formulation on STYL'One Evo compaction simulator


Why should you watch?

  • Learn about fundamental challenges when developping multilayer tablets
  • Learn about layer adhesion of bi-layer tablets
  • Learn how to develop a multilayer formulation with a compaction simulator
  • Determine optimal process parameters for multilayer tablets in little time with only a few grams of material

#multilayer #webinar #bilayer tablets #replay

Feature article

pharmaceutical-technology

July 25, 2022

How to mitigate risks in process scale-up ?

On this article you will find how pharmaceutical companies can improve the efficiency of their entire product development and drug commercialisation process with the ever-rising costs of bringing a drug to market. A well-known source of bottlenecks, delays, and technical setbacks is process scale-up, where production moves from the laboratory to full-scale GMP manufacturing

#multilayer #manufacture #tablet #containment #HPAPI

Announcement

MySTYL'One

Sept. 19, 2022

Impact of alternative lubricants on process and tablet quality for direct compression


In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The study is available in the PAPERS section.

Find others papers here and learn about

  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • Tablet formulation development focusing on the functional behaviour of water uptake and swelling
  • Mean yield pressure from the in-die Heckel analysis is a reliable plast...

In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The study is available in the PAPERS section.

Find others papers here and learn about

  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • Tablet formulation development focusing on the functional behaviour of water uptake and swelling
  • Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

#Direct Compression #magnesium stearate #tableting #lubrication #compaction simulator

Feature article

MySTYL'One

Sept. 8, 2022

Webinar Transcript - Fundamental Investigations on Bilayer Tablets

Access the transcript of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" 

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig & Senior Scientist, Fraunhofer IST
*Bruno Leclercq, Science Lab Head and Business Development Manager, MEDELPHARM

Webinar agenda: 

  • General Introduction
  • Measurement of interfacial adhesion strength 
  • Influence of material deformation behaviour & impact of process parameters and tablet geometry
  • Detection of signs of internal stresses before delamination 

#bilayer tablets #webinar #transcript

Announcement

MySTYL'One

Sept. 2, 2022

Commercial scale transfer of a twin-screw melt granulation process for high drug load fevipiprant tablets


The present work summarizes select methodology of twin-screw melt granulation (TSMG) and process analytical technology that were used in the successful scaling-up and commercial transfer of high drug load (80.5% w/w) immediate release fevipiprant tablets. The study is available in the PAPERS section.

Find others papers here and learn about

  • Roller Compaction Scale-Up Made Simple: An Approximate Analytical Solution to Johanson's Rolling Theory
  • Integrating QbD Tools for Flexible Scale-Up Batch Size Selection for Solid Dosage Forms
  • Model-based approach to the design of pharmaceutical roller-compaction processes

#commercial technology transfer #melt granulation #scaling up #twin-screw #high drug load tablets #near-infrared spectroscopy #process-analytical technology

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