MySTYL'One
July 22, 2022
The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.
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pharmaceutical-technology
July 20, 2022
Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance pat...
Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance patient care. Meanwhile, the processes and equipment it uses to manufacture these products are also advancing.
MySTYL'One
July 11, 2022
The present works demonstrated the feasibility of producing high drug load minitablets from a cohesive, electrostatic–prone fine drug powder. The study is available in the PAPERS section.
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#STYL'One Nano #manufacturing #parameters #database #optimization
CPhI Global Pharma Events
July 9, 2022
MySTYL'One members exclusive!
CPhI worldwide 2018
Conference in the ICSE theatre : Compression Simulation as a Powerful Quality by Design (QbD) Tool
Animated by Aline Moulin, Senior Project Manager - Pharmaceutical Development
#STYL'One evo #scale-up #optimization #QbD #compaction simulator #conference #prototype
University of Strathclyde
July 3, 2022
This platform aims to create a unique autonomous microscale drug product manufacturing and testing system to select formulation and process parameters that result in a stable product with desired critical quality attributes. The number of experiments increases drastically with the number of excipients, drug loadings and process conditions that need to be explored to find the optimal formulation and process settings. Integrating industrial digital technologies (IDTs) with innovative pharmaceut...
This platform aims to create a unique autonomous microscale drug product manufacturing and testing system to select formulation and process parameters that result in a stable product with desired critical quality attributes. The number of experiments increases drastically with the number of excipients, drug loadings and process conditions that need to be explored to find the optimal formulation and process settings. Integrating industrial digital technologies (IDTs) with innovative pharmaceutical process technologies will de-risk and accelerate drug product manufacture, reducing experiments and dramatically reducing development time and raw material/solvents use by 60%, whilst achieving CQA objectives by self-optimized formulation and process conditions. The platform is codeveloped and co-delivered with industry partners focusing on 1) tablets (via direct compression) and 2) capsules (via powder fill) . The initial aim of this platform is to deliver an automated microscale batch manufacturing system that ca n eliminate waste while preparing tablet batches of < 10 g per batch and < 50 tablets per batch.
#Artificial Intelligence #DM2 #AI #Digital Medicines Manufacturing #Drug manufacturing #R&D
MySTYL'One
June 29, 2022
The University of Copenhagen presents a work on an approach for development of the optimal tablet formulation as well as gaining an understanding on how the selection of excipients and manufacturing processes ultimately influences tablet disintegration.Medelpharm is part of this innovative project. Full paper available in the PAPERS section.
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#STYL'One #Tablet disintegration #multivariate data analysis #tablet disintegration kinetics #image analysis #imaging
Korsch.com
June 27, 2022
KORSCH AG conducted revealing interviews with customers on this magazine focused on Research and Development. It provides a detailed insight into the processes and challenges involved in successful product development, including a look over the shoulders of experts at the KORSCH INNOVATION CENTER in Berlin and MEDELPHARM Science Lab in Lyon.
MySTYL'One
June 23, 2022
The present works detail an ambitious “Digital Medicines Manufacturing" (DM²) program, which aims to transform medicines development and manufacturing productivity, driving patient-centric supply through the creation and adoption of Industrial Digital Technologies (IDTs). Medelpharm is part of this innovative project. The 2 posters talking on it are available in the PAPERS section.
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#STYL'One Nano #manufacturing #parameters #database #optimization