Newsroom, your daily review

Keep up with the latest in the tableting community!


Announcement

MySTYL'One

July 22, 2022

On the complexity of predicting tablet capping


The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.

Find others papers here and learn about

  • Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
  • Enabling the direct compression of metformin hydrochloride through QESD crystallization
  • Role of Precompression in the Mitigation of Capping: A Case Study

#STYL'One evo #tablet #compaction #decision tree #capping

Feature article

pharmaceutical-technology

July 20, 2022

Pharmaceutical Technology - Top trends in tablet manufacturing

Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance pat...

Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance patient care. Meanwhile, the processes and equipment it uses to manufacture these products are also advancing.

#multilayer #manufacture #tablet #containment #HPAPI

Announcement

MySTYL'One

July 11, 2022

Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets


The present works demonstrated the feasibility of producing high drug load minitablets from a cohesive, electrostatic–prone fine drug powder. The study is available in the PAPERS section.

Find others papers here and learn about

  • Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions
  • Influence of the porosity of cushioning excipients on the compaction of coated multi-particulates
  • Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose

#STYL'One Nano #manufacturing #parameters #database #optimization

Video

Alix Software

July 11, 2022

TUTO 02 - How to input tablets metrics manually or automatically ?

MySTYL'One members exclusive!

Here is your Tutorial session for a better understanding of new features on Alix Software.

#Data #software #stylone #alix #tablet tester #tutorial

Video

CPhI Global Pharma Events

July 9, 2022

Flashback on Skyepharma conference on Compaction simulation at CPhI worldwide edition 2018

MySTYL'One members exclusive!

CPhI worldwide 2018

Conference in the ICSE theatre : Compression Simulation as a Powerful Quality by Design (QbD) Tool

Animated by Aline Moulin, Senior Project Manager - Pharmaceutical Development

#STYL'One evo #scale-up #optimization #QbD #compaction simulator #conference #prototype

Video

Alix Software

July 6, 2022

TUTO 01 - How to create graph from your studies ?

MySTYL'One members exclusive!

Here is your Tutorial session for a better understanding of new features on Alix Software.

#Data #software #stylone #alix #chart #tutorial #analysis

Feature article

University of Strathclyde

July 3, 2022

Project DM² - Development of an Automated Microscale Manufacturing System for Oral Solid Dosage Forms

This platform aims to create a unique autonomous microscale drug product manufacturing and testing system to select formulation and process parameters that result in a stable product with desired critical quality attributes. The number of experiments increases drastically with the number of excipients, drug loadings and process conditions that need to be explored to find the optimal formulation and process settings. Integrating industrial digital technologies (IDTs) with innovative pharmaceut...

This platform aims to create a unique autonomous microscale drug product manufacturing and testing system to select formulation and process parameters that result in a stable product with desired critical quality attributes. The number of experiments increases drastically with the number of excipients, drug loadings and process conditions that need to be explored to find the optimal formulation and process settings. Integrating industrial digital technologies (IDTs) with innovative pharmaceutical process technologies will de-risk and accelerate drug product manufacture, reducing experiments and dramatically reducing development time and raw material/solvents use by 60%, whilst achieving CQA objectives by self-optimized formulation and process conditions. The platform is codeveloped and co-delivered with industry partners focusing on 1) tablets (via direct compression) and 2) capsules (via powder fill) . The initial aim of this platform is to deliver an automated microscale batch manufacturing system that ca n eliminate waste while preparing tablet batches of < 10 g per batch and < 50 tablets per batch.

#Artificial Intelligence #DM2 #AI #Digital Medicines Manufacturing #Drug manufacturing #R&D

Announcement

MySTYL'One

June 29, 2022

A generalized image analytical algorithm for investigating tablet disintegration


The University of Copenhagen presents a work on an approach for development of the optimal tablet formulation as well as gaining an understanding on how the selection of excipients and manufacturing processes ultimately influences tablet disintegration.Medelpharm is part of this innovative project. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces
  • Predictive selection rule of favourable image processing methods for X-ray micro-computed tomography images of tablets
  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

#STYL'One #Tablet disintegration #multivariate data analysis #tablet disintegration kinetics #image analysis #imaging

Feature article

Korsch.com

June 27, 2022

KORSCH Magazine - Research & Development, our customers respond

KORSCH AG conducted revealing interviews with customers on this magazine focused on Research and Development. It provides a detailed insight into the processes and challenges involved in successful product development, including a look over the shoulders of experts at the KORSCH INNOVATION CENTER in Berlin and MEDELPHARM Science Lab in Lyon.

#R&D #KORSCH #process #magazine #issue

Announcement

MySTYL'One

June 23, 2022

Development and optimization of an Automated Microscale Manufacturing System for Oral Solid Dosage Forms


The present works detail an ambitious “Digital Medicines Manufacturing" (DM²) program, which aims to transform medicines development and manufacturing productivity, driving patient-centric supply through the creation and adoption of Industrial Digital Technologies (IDTs). Medelpharm is part of this innovative project. The 2 posters talking on it are available in the PAPERS section.

Find others papers here and learn about

  • Predictive modelling of powder compaction for binary mixtures using the finite element method
  • Amorphous-based controlled-release gliclazide matrix system
  • Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression

#STYL'One Nano #manufacturing #parameters #database #optimization

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