Newsroom, your daily review

Keep up with the latest in the tableting community!


Announcement

MySTYL'One

Jan. 12, 2023

Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders


In this paper you will find a study showing that surface characteristics and preprocessing can prevail over the impact of polymorphism on manufacturability for oral solid dosage forms. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling
  • Transformation Induite au cours d'un Procédé Industriel (TIPI) de compression directe: transition poly...

In this paper you will find a study showing that surface characteristics and preprocessing can prevail over the impact of polymorphism on manufacturability for oral solid dosage forms. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Novel Polyurethane Matrix Systems Reveal a Particular Sustained Release Behavior Studied by Imaging and Computational Modeling
  • Transformation Induite au cours d'un Procédé Industriel (TIPI) de compression directe: transition polymorphique de la caféine et propriétés physiques des comprimés
  • Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior

#mannitol #roller compaction #direct compression #polymorphism #powder characterization #tabletability

Announcement

MySTYL'One

Dec. 20, 2022

Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression


In this paper you will find a study that investigates on Hydrochlorothiazide/Losartan Potassium used to prepare compound tablets through the investigation of the compression and mechanical properties of mixed powders to determine the formulation and preparation factors. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • A mechanistic understanding of compres...

In this paper you will find a study that investigates on Hydrochlorothiazide/Losartan Potassium used to prepare compound tablets through the investigation of the compression and mechanical properties of mixed powders to determine the formulation and preparation factors. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets
  • Investigation of Compressibility Characteristics of Paracetamol using Compaction Simulator

#STYL'One #mechanical properties #direct compression #dissolution rate #bioavailibility #compression properties

Feature article

MySTYL'One

Dec. 19, 2022

Webinar replay - Dosage Form Design & Patient Compliance: Exploring ODTs as a Patient-centric Solution

Get access for this online event replay.

Date: Friday, January 27th, 2022
Time: 11am EST/4PM GMT/8am PST
Duration: 60 minutes

"Dosage Form Design & Patient Compliance: Exploring ODTs as a Patient-centric Solution" - by David Elder, Principal Consultanl - David P Elder Consultancy, and Ralph Gosden, Head of Zydis Product Development - Catalent.

#webinar #STYLOne #catalent #dosage form

Video

Thermofisher Scientific

Nov. 23, 2022

Material matters: Material Science, Process Simulation and Modeling for Oral Solid Dosage Forms

With the ever-growing pressure to get new therapies to patients faster, predictive modeling and simulation tools are increasingly recognized as critical enabling technologies for accelerating drug product development. In the development of oral solid dosage forms, predictive modeling and simulation tools of the manufacturing processes can enhance process understanding, save on API supply, improve product quality, and reduce or eliminate many of the bottlenecks associated with empirical method...

With the ever-growing pressure to get new therapies to patients faster, predictive modeling and simulation tools are increasingly recognized as critical enabling technologies for accelerating drug product development. In the development of oral solid dosage forms, predictive modeling and simulation tools of the manufacturing processes can enhance process understanding, save on API supply, improve product quality, and reduce or eliminate many of the bottlenecks associated with empirical methods.

Each active pharmaceutical ingredient (API) has its own set of unique physical and chemical properties that can affect the success of product formulations and manufacturing routes. On account of this, the manufacturing process for solid dosage forms need to be thoroughly understood. Determining robust formulations and processes for a given compound requires a deep understanding of material science and powder behavior.

#R&D #STYL'One evo #Powder compaction #science lab #Material science

Feature article

Adare Pharma Solutions

Oct. 20, 2022

Taste Masking 101: Optimize Taste and Improve Patient Outcomes

Taste masking, combined with swallowability and palatability, are integral considerations for oral drug formulations; ensuring both as part of a drug product’s final formulation can serve to increase patient acceptability and adherence to the therapy, which in turn can bolster regulatory acceptance and commercial potential.

#drug formulation #pediatric drug development #dosage form

Feature article

Adare Pharma Solutions

Oct. 6, 2022

Formulation Considerations for Pediatric Populations: Finding the Right Dosage Form for Better Adherence

To address the challenges of pediatric formulations, specialized technology platforms are often needed to provide ease of application and improve patient outcomes.

#drug formulation #pediatric drug development #dosage form

Announcement

MySTYL'One

July 26, 2022

Replay: "Fundamental Investigations on Bilayer Tablets"

Replay of the webinar 

--> MySTYL'One members: access the webinar page for the full replay

--> Not a member, but would like to view the video? Fill out online request form: https://form.jotform.com/222024289539055 

Access the replay of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" with thanks to the links above.

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig &am...

Replay of the webinar 

--> MySTYL'One members: access the webinar page for the full replay

--> Not a member, but would like to view the video? Fill out online request form: https://form.jotform.com/222024289539055 

Access the replay of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" with thanks to the links above.

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig & Senior Scientist, Fraunhofer IST
*Bruno Leclercq, Science Lab Head and Business Development Manager, MEDELPHARM

Webinar agenda: 

  • Measurement of interfacial adhesion strength 
  • Influence of material deformation behaviour & impact of process parameters and tablet geometry
  • Detection of signs of internal stresses before delamination 
  • Demonstration of multilayer tablet formulation on STYL'One Evo compaction simulator


Why should you watch?

  • Learn about fundamental challenges when developping multilayer tablets
  • Learn about layer adhesion of bi-layer tablets
  • Learn how to develop a multilayer formulation with a compaction simulator
  • Determine optimal process parameters for multilayer tablets in little time with only a few grams of material

#multilayer #webinar #bilayer tablets #replay

Feature article

pharmaceutical-technology

July 25, 2022

How to mitigate risks in process scale-up ?

On this article you will find how pharmaceutical companies can improve the efficiency of their entire product development and drug commercialisation process with the ever-rising costs of bringing a drug to market. A well-known source of bottlenecks, delays, and technical setbacks is process scale-up, where production moves from the laboratory to full-scale GMP manufacturing

#multilayer #manufacture #tablet #containment #HPAPI

Feature article

MySTYL'One

Sept. 8, 2022

Webinar Transcript - Fundamental Investigations on Bilayer Tablets

Access the transcript of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" 

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig & Senior Scientist, Fraunhofer IST
*Bruno Leclercq, Science Lab Head and Business Development Manager, MEDELPHARM

Webinar agenda: 

  • General Introduction
  • Measurement of interfacial adhesion strength 
  • Influence of material deformation behaviour & im...

Access the transcript of the webinar "Fundamental Investigations on Bilayer tablets - Effects of Process Parameters and Geometry on Interfacial Strength" 

Speakers:
*Jan Finke, Division Head Pharma & Bioparticle Technology, iPAT, TU Braunschweig & Senior Scientist, Fraunhofer IST
*Bruno Leclercq, Science Lab Head and Business Development Manager, MEDELPHARM

Webinar agenda: 

  • General Introduction
  • Measurement of interfacial adhesion strength 
  • Influence of material deformation behaviour & impact of process parameters and tablet geometry
  • Detection of signs of internal stresses before delamination 

#bilayer tablets #webinar #transcript

Announcement

MySTYL'One

July 22, 2022

On the complexity of predicting tablet capping


The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.

Find others papers here and learn about

  • Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
  • Enabling the direct compression of metformin hydrochloride through QESD crystallization
  • Role of Precompression in the Mitigation of Capping: A Case Study

#STYL'One evo #tablet #compaction #decision tree #capping

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