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Showing posts tagged as : #Compaction simulation

Announcement

MySTYL'One

May 25, 2023

Upscaling of external lubrication from a compaction simulator to a rotary tablet press

New paper from Ghent university. 

External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction simulator and rotary tablet press using three lubricants (magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and glyceryl dibehenate (DBHG)).

In conclusion, the potent...

New paper from Ghent university. 

External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction simulator and rotary tablet press using three lubricants (magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and glyceryl dibehenate (DBHG)).

In conclusion, the potential of external lubrication for implementation on production scale tableting equipment and during scale-up was demonstrated for multiple lubricants.

More information in the papers section.

You can also find related papers on externa lubrication:

  •    Screening of lubricants towards their applicability for external lubrication
  • ·  Effect of binder type and lubrication method on the binder efficacy for direct compression
  • ·  Evaluation of an external lubrication system implemented in a compaction simulator

#rotary tablet press #direct compression #external lubrication #Compaction simulation #tablet properties #magnesium stearate

Press review

MySTYL'One

May 9, 2023

Looking into the OSD Crystal Ball: Industry Experts Reflect on Opportunities and Challenges in 2023 and Beyond

Tablets & capsules dives into oral solid dosage forms and the opportunities and challenges in 2023 and beyond:

  • Materials-sparing formulations will see higher uptake

Materials-sparing formulation development approaches enabled by compaction simulation will be widely adopted. Rich information on the properties and performance of API and blends can be collected using grams of material on a compaction simulator. Punch sticking, air entrapment, speed effect, tooling design, and other process parameters can be studied to optimize formulation and manufacturing process so that they are amenable for commercial manufacturing.

Additional topics:

  • The future of Quality in Manufacturing
  • More automation in testing
  • Customization is coming
  • A renewed emphasis on sustainability strategies
  • Persistent Multiple Cost Pressures 
  • Better tool management

Full news available on Tablets & Capsules.

#tool management #Compaction simulation #material sparing #sustainability #Pharma 4.0 #customization #automation

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