In this paper you will find a study that focuses on the assessment of the capping problem using computer modelling of the pharmaceutical powder compression and consolidation process using the finite element analysis (FEA) method implementing the Drucker–Prager Cap (DPC) model. The paper is available in the PAPERS section.

Find others papers here and learn about

• Characterization of Tableting Speed-Dependent Deformation Properties of Active Pharmaceutical Ingredients in Powder Mixtures Using Out-of-Die Method
  
• Influence of the unloading conditions on capping and lamination: Study on a compaction simulator
  
• Shear strength of pharmaceutical tablets: Theoretical considerations, evaluation and relation with the capping tendency of biconvex tablets
  

With the ever-growing pressure to get new therapies to patients faster, predictive modeling and simulation tools are increasingly recognized as critical enabling technologies for accelerating drug product development. In the development of oral solid dosage forms, predictive modeling and simulation tools of the manufacturing processes can enhance process understanding, save on API supply, improve product quality, and reduce or eliminate many of the bottlenecks associated with empirical methods.

Each active pharmaceutical ingredient (API) has its own set of unique physical and chemical properties that can affect the success of product formulations and manufacturing routes. On account of this, the manufacturing process for solid dosage forms need to be thoroughly understood. Determining robust formulations and processes for a given compound requires a deep understanding of material science and powder behavior.

The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

• Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
• Novel ultrasonic in-die measurements during powder compression at production relevant speed
  
• Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces