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Showing posts tagged as : #Powder compaction

Video

Thermofisher Scientific

Nov. 23, 2022

Material matters: Material Science, Process Simulation and Modeling for Oral Solid Dosage Forms

With the ever-growing pressure to get new therapies to patients faster, predictive modeling and simulation tools are increasingly recognized as critical enabling technologies for accelerating drug product development. In the development of oral solid dosage forms, predictive modeling and simulation tools of the manufacturing processes can enhance process understanding, save on API supply, improve product quality, and reduce or eliminate many of the bottlenecks associated with empirical method...

With the ever-growing pressure to get new therapies to patients faster, predictive modeling and simulation tools are increasingly recognized as critical enabling technologies for accelerating drug product development. In the development of oral solid dosage forms, predictive modeling and simulation tools of the manufacturing processes can enhance process understanding, save on API supply, improve product quality, and reduce or eliminate many of the bottlenecks associated with empirical methods.

Each active pharmaceutical ingredient (API) has its own set of unique physical and chemical properties that can affect the success of product formulations and manufacturing routes. On account of this, the manufacturing process for solid dosage forms need to be thoroughly understood. Determining robust formulations and processes for a given compound requires a deep understanding of material science and powder behavior.

#R&D #STYL'One evo #Powder compaction #science lab #Material science

Announcement

MySTYL'One

April 28, 2022

Predictive modelling of powder compaction for binary mixtures using the finite element method


The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
  • Novel ultrasonic in-die measurements during ...

The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
  • Novel ultrasonic in-die measurements during powder compression at production relevant speed
  • Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

#formulation #Predictive modelling #mechanical properties #Mixing model #Powder compaction #STYLOne #Drucker-Prager Cap model

Announcement

MySTYL'One

April 11, 2022

Effect of feedframe on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press


The present work details the effect of lubricant blending time and Paddle Speed of forced feeders on the tensile strength of lubricated microcrystalline cellulose (MCC) and lactose tablets. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Prediction of the impact of lubrication on tablet compactibility
  • Transfer and scale-up of the manufacturing of orodispetsible mini-tablet from a compaction simulator to an industrial rotary tablet press
  • Tablet formulation development focusing on the functional behaviour of water uptake and swelling

#Internal lubrication #Lubricant sensitivity #Upscaling #Powder compaction #compaction simulator #Direct Compression

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