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Showing posts tagged as : #STYL'One

Announcement

MySTYL'One

May 10, 2023

The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

This work summarizes the findings from the collection of DPC parameters from 60 materials. From this dataset several important conclusions can be drawn about typical and extreme behaviors of formulations and excipients. From these findings key signals of program risk can be determined and utilized early in the formulation development process to avoid costly manufacturing and scale-up issues.

The paper is available in the PAPERS section.

Find others studies here using the Drucker-Prager Cap mode...

This work summarizes the findings from the collection of DPC parameters from 60 materials. From this dataset several important conclusions can be drawn about typical and extreme behaviors of formulations and excipients. From these findings key signals of program risk can be determined and utilized early in the formulation development process to avoid costly manufacturing and scale-up issues.

The paper is available in the PAPERS section.

Find others studies here using the Drucker-Prager Cap model:

  • Predictive modelling of powder compaction for binary mixtures using the finite element method
  • Comparative study between Drucker-Prager/Cap and modified Cam-Clay models for the numerical simulation of die compaction of pharmaceutical powders

#finite elements methods #STYL'One #compaction #Drucker-Prager Cap model #DPC

Feature article

MySTYL'One

April 12, 2023

STYL'One User Group 2023 - Call for Abstract

MySTYL'One user exclusive!

Call for abstracts - STYL'One User Group at MEDELPHARM Lyon, France.

#Lyon #meeting #STYL'One #User Group #France

Feature article

MySTYL'One

March 31, 2023

STYL'One User Group 2023

MySTYL'One user exclusive!

Save the date - STYL'One User Group at MEDELPHARM Lyon, France.

#Lyon #meeting #STYL'One #User Group #France

Announcement

MySTYL'One

March 28, 2023

Screening of lubricants towards their applicability for external lubrication


In this paper you will find a study that focuses on the ejection forces through external lubrication from a compaction simulator and shows how significantly lower lubricant concentrations are achieved than with internal lubrication.. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Upscaling of external lubrication from a compaction simulator to a rotary tablet press
  • Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conven...

In this paper you will find a study that focuses on the ejection forces through external lubrication from a compaction simulator and shows how significantly lower lubricant concentrations are achieved than with internal lubrication.. The paper is available in the PAPERS section.

Find others papers here and learn about

  • Upscaling of external lubrication from a compaction simulator to a rotary tablet press
  • Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets
  • Impact of alternative lubricants on process and tablet quality for direct compression

#STYL'One #external lubrication #compaction simulator

Announcement

MySTYL'One

June 29, 2022

A generalized image analytical algorithm for investigating tablet disintegration


The University of Copenhagen presents a work on an approach for development of the optimal tablet formulation as well as gaining an understanding on how the selection of excipients and manufacturing processes ultimately influences tablet disintegration.Medelpharm is part of this innovative project. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-W...

The University of Copenhagen presents a work on an approach for development of the optimal tablet formulation as well as gaining an understanding on how the selection of excipients and manufacturing processes ultimately influences tablet disintegration.Medelpharm is part of this innovative project. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces
  • Predictive selection rule of favourable image processing methods for X-ray micro-computed tomography images of tablets
  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa

#STYL'One #Tablet disintegration #multivariate data analysis #tablet disintegration kinetics #image analysis #imaging

Announcement

MySTYL'One

April 11, 2022

Physicochemical Changes and Chemical Degradation of Gliclazide during Twin-Screw Melt Granulation


The present work details how the twin-screw melt granulation process affects the chemical stability and process-induced physicochemical changes of the drug. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Structure-property relationship of Amorphous Maltitol as Tableting Excipient
  • Development of Coprocessed Chitin-Calcium Carbonate as Multifunctional Tablet Excipient for Direct Compression
  • Simulations of Drug Realease Profiles as a Function of Different Geometr...

The present work details how the twin-screw melt granulation process affects the chemical stability and process-induced physicochemical changes of the drug. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Structure-property relationship of Amorphous Maltitol as Tableting Excipient
  • Development of Coprocessed Chitin-Calcium Carbonate as Multifunctional Tablet Excipient for Direct Compression
  • Simulations of Drug Realease Profiles as a Function of Different Geometrical Designs

#granulation process #STYL'One #Gliclazide #degradation #kneading element

Announcement

MySTYL'One

April 4, 2022

Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa


The present work details the development of an oral solid dosage form to address the rare disease epidermolysis bullosa, which can appear already in newborn children. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press
  • QbD approach formulation design for metformin HCI and evaluations
  • Tableting of mini-tablets in comparison with ...

The present work details the development of an oral solid dosage form to address the rare disease epidermolysis bullosa, which can appear already in newborn children. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press
  • QbD approach formulation design for metformin HCI and evaluations
  • Tableting of mini-tablets in comparison with conventionally sized tablets: A comparison of tableting properties and tablet dimensions

#STYL'One #stability #epidermolysis bullosa #losartan potassium #dry granulation #paediatrics #rare disease #mini-tablets #coating

Announcement

MySTYL'One

March 30, 2022

Why Tabletability Assessment Of Your Formulation Is A Fundamental Step Of Your Tablet Development ?


MySTYL'One user exclusive!

New bulletin available on fundamental step in a tablet development. This case study highlight how quickly excipients or powder blends can be compared thanks to tabletability profiles.

#bulletin #formulation #STYL'One #production #tabletability

Announcement

MySTYL'One

Feb. 7, 2022

Granutools Pharma User Club webinar - Replay available

On January 27th, 2022 Granutools organized their User Club Meeting for members of the pharmaceutical sector. 

This virtual meeting was the occasion to hear case studies presented by speakers who use Granutools equipment for their work. 

Delphine Ach-Hubert, formulation scientist at MEDELPHARM, presented case studies on particle size influence on tableting properties, using Granutools equipment and the STYL'One Evo compaction simulator. 

Replay available HERE

#webinar #STYL'One #Granutools #particle size

Feature article

MySTYL'One

Jan. 12, 2022

STYL'One Nano Live Demo


New event open to MySTYL'One members!

Join us for the STYL’One Nano Live Demo!

Wednesday January 19th, 4 pm - 5 pm (Paris Time)

#STYL'One Nano #STYL'One #live demo #online

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