MySTYL'One user exclusive!

New bulletin available detailing processes used to achieve enhanced bioavailability of Itraconazole (ITZ):

• amorphous solid dispersions of ITZ in a polymer matrix were produced using Hot Melt Extrusion
• ASDS improve the poor solubility 
• but impaires the tableting stage 

MySTYL'One members exclusive!

Here is your Tutorial session for a better understanding of new features on Alix Software.

Mariana Bezerra (De Montfort University, Leicester UK) tells you more on DoE and the MEDELPHARM Science Lab shows how it can be performed on a STYL'One nano

• Selecting designs based on experimental goals - screening, optimisation, robustness
• Exploring powder compaction attributes in formulation development
• Building data driven models to predict tablet performance

The present works demonstrated the feasibility of producing high drug load minitablets from a cohesive, electrostatic–prone fine drug powder. The study is available in the PAPERS section.

Find others papers here and learn about

• Tablet Disintegration and Dispersion under In Vivo-like Hydrodynamic Conditions
  
• Influence of the porosity of cushioning excipients on the compaction of coated multi-particulates
  
• Effects of Particle Surface Roughness on In-Die Flow and Tableting Behavior of Lactose
  

The present works detail an ambitious “Digital Medicines Manufacturing" (DM²) program, which aims to transform medicines development and manufacturing productivity, driving patient-centric supply through the creation and adoption of Industrial Digital Technologies (IDTs). Medelpharm is part of this innovative project. The 2 posters talking on it are available in the PAPERS section.

Find others papers here and learn about

• Predictive modelling of powder compaction for binary mixtures using the fi...

MySTYL'One user exclusive!

Head to the bulletins section and dive into the V-shape compression cycle available on the STYL'One Nano for powder characterization with real speed sensitivity.

Let's discover MEDELPHARM, a campany specialized in solutions for drug development process for solid dose pharmaceutical product. All processes are concerned, including "extensive formulation development, preclinical testing and clinical trials..."

Click here for full article.