In this paper you will find an investigation on the compressibility constant as an in-die method and has been compared with the Heckel analysis for describing the compressibility of materials during tableting. The paper is available in the PAPERS section.

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• Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter
  
• Process Modeling and Simulation of Tableting—An Agent-Based Simulation Methodology for Direct Compression
  
• Immediate-Re...

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Date: Friday, January 27th, 2022
Time: 11am EST/4PM GMT/8am PST
Duration: 60 minutes

"Dosage Form Design & Patient Compliance: Exploring ODTs as a Patient-centric Solution" - by David Elder, Principal Consultanl - David P Elder Consultancy, and Ralph Gosden, Head of Zydis Product Development - Catalent.

The present work details the influence of the unloading step on capping using a compaction simulator. Full paper available in the PAPERS section.

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• Studying the impact of lubrication on tablet properties using STYL'One
  
• The effect of spray drying on the compaction properties of hypromellose acetate succinate

The present work details solubility of BCS class II, nevirapine using solid dispersions, SeDeM analyses of excipients and solid dispersions to analyze direct compressibility  and orodispersibility tablets (ODT).

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• Structure-Property Relationship of Amorphous Maltitol as Tableting Excipient
  
• Evaluation of an external lubrication system implemented in a compaction simulator

The present work details the effect of the used tooling system on quality attributes during manufacturing mini-tablets. Full paper available in the PAPERS section.

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• Transfer and scale-up of the manufacturing of orodispersible mini-tablets from a compaction simulator to an industrial rotary tablet press
  
• Investigation of critical factors affecting mechanical characteristics of press-coated tablets using a compaction simulator
  
• Along the Process Chain to Probiot...

The present work details how moisture sorption properties of the starches with different amylose-amylopectin ratio impacted tablet properties including drug stability. Full paper available in the PAPERS section.

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• Compression Profiles of a Directly Compressible Starch using Compaction Simulation and High-Speed Tablet Press
  
• Insights into the Moisture Scavenging Properties of Different Types of Starch in Tablets Containing a Moisture-Sensitive Drug
  
• Starch-based...

The present work details a model based on the Ryshkewitch-Duckworth equation that can estimate the compactibility profiles of lubricated formulations. Available model showing extended quantitative predictive accuracy for the influence of lubricant concentration on the mechanical strength of tablets. Full paper available in the PAPERS section.

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• Effect of binder type and lubrication method on the binder efficacy for direct compression
  
• Evaluation of an externa...

The present work details powder compaction simulations, using the finite element method (FEM) in combination with the density-dependent Drucker-Prager Cap model, which can be used to aid the design process of pharmaceutical tablets. Full paper available in the PAPERS section.

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• Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters
• Novel ultrasonic in-die measurements during ...

The present work in mechanistic process modeling presents an opportunity to reduce experimental burden, enabling relationships between process parameters and product attributes to be mapped out using in-silico experiments. Full paper available in the PAPERS section.

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• Investigating key properties of model excipients and binary powder blends using ultrasonic in-die measurements on a compaction simulator 
• Impact of Incorporated Drugs on Material Properties of ...