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Showing posts tagged as : #capping

Feature article

Medelpharm

Jan. 18, 2023

Tableting Rheology and Quality by Design

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have...

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have speed limits! Speed sensitivity may also be called strain rate sensitivity. The penalty for exceeding the speed limit is capping, making tablet production impossible. During development capping/lamination is unacceptable for further progression.

#viscoelasticity #tablet development #scale-up #Quality by Design #capping

Announcement

MySTYL'One

July 22, 2022

On the complexity of predicting tablet capping


The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.

Find others papers here and learn about

  • Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
  • Enabling the direct compression of metformin hydrochloride through QESD crystallization
  • Role of Precompression in the Mitigation of Capping: A Case Study

#STYL'One evo #tablet #compaction #decision tree #capping

Announcement

MySTYL'One

June 20, 2022

Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets


The present work details the influence of the unloading step on capping using a compaction simulator. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Studying the impact of lubrication on tablet properties using STYL'One
  • The effect of spray drying on the compaction properties of hypromellose acetate succinate

#tableting #capping #compression #STYLOne #tablet #Defects

Video

Vincent Mazel - University of Bordeaux

May 15, 2021

Video replay - Influence of the unloading conditions on capping and lamination during tableting

MySTYL'One members exclusive!

Watch the replay of the presentation delivered by Vincent Mazel (user of a STYL'One Evolution, University of Bordeaux, France) during the 12th APV PBP World meeting.

#video #capping #lamination #study #university of Bordeaux #unloading #webinar

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