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Showing posts tagged as : #compaction

Announcement

MySTYL'One

May 10, 2023

The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

This work summarizes the findings from the collection of DPC parameters from 60 materials. From this dataset several important conclusions can be drawn about typical and extreme behaviors of formulations and excipients. From these findings key signals of program risk can be determined and utilized early in the formulation development process to avoid costly manufacturing and scale-up issues.

The paper is available in the PAPERS section.

Find others studies here using the Drucker-Prager Cap mode...

This work summarizes the findings from the collection of DPC parameters from 60 materials. From this dataset several important conclusions can be drawn about typical and extreme behaviors of formulations and excipients. From these findings key signals of program risk can be determined and utilized early in the formulation development process to avoid costly manufacturing and scale-up issues.

The paper is available in the PAPERS section.

Find others studies here using the Drucker-Prager Cap model:

  • Predictive modelling of powder compaction for binary mixtures using the finite element method
  • Comparative study between Drucker-Prager/Cap and modified Cam-Clay models for the numerical simulation of die compaction of pharmaceutical powders

#finite elements methods #STYL'One #compaction #Drucker-Prager Cap model #DPC

Announcement

MySTYL'One

July 22, 2022

On the complexity of predicting tablet capping


The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.

Find others papers here and learn about

  • Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
  • Enabling the direct compression of metformin hydrochloride through QESD crystallization
  • Role of Precompression in the Mitigation of Capping: A Case Study

#STYL'One evo #tablet #compaction #decision tree #capping

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