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Showing posts tagged as : #direct compression

Press review

MySTYL'One

May 26, 2023

Particle Engineering via QESD crystallization

The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet. 

This review mainly focuses on various dosage forms like Solid, Sem...

The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet. 

This review mainly focuses on various dosage forms like Solid, Semisolid, Liquisolid, and Solidified liquid dosage forms. These techniques mainly characterize all substances using 12 parameters, resulting 12-sided regular polygon.

This new paper is available here on MySTYL’One

#direct compression #metformin hydrocholoride #granulation

Announcement

MySTYL'One

May 25, 2023

Upscaling of external lubrication from a compaction simulator to a rotary tablet press

New paper from Ghent university. 

External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction simulator and rotary tablet press using three lubricants (magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and glyceryl dibehenate (DBHG)).

In conclusion, the potent...

New paper from Ghent university. 

External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with automated external lubrication systems implemented in a compaction simulator and rotary tablet press using three lubricants (magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and glyceryl dibehenate (DBHG)).

In conclusion, the potential of external lubrication for implementation on production scale tableting equipment and during scale-up was demonstrated for multiple lubricants.

More information in the papers section.

You can also find related papers on externa lubrication:

  •    Screening of lubricants towards their applicability for external lubrication
  • ·  Effect of binder type and lubrication method on the binder efficacy for direct compression
  • ·  Evaluation of an external lubrication system implemented in a compaction simulator

#rotary tablet press #direct compression #external lubrication #Compaction simulation #tablet properties #magnesium stearate

Press review

MySTYL'One

Oct. 30, 2020

Roller compaction: new trends, challenges and solutions

Read the article from Catalent explaining the 3 known technologies to develop tablets:

- direct compression
- wet granulation
- dry granulation, 

with a focus on roller compaction, as it remains an effective solution for most APIs, in particular those as amorphous solid dispersions.

#direct compression #dry granulation #Roller compaction #wet granulation

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