The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet. 

This review mainly focuses on various dosage forms like Solid, Semisolid, Liquisolid, and Solidified liquid dosage forms. These techniques mainly characterize all substances using 12 parameters, resulting 12-sided regular polygon.

This new paper is available here on MySTYL’One. 

This paper examines the influence of pharmaceutical processing techniques on the properties of high drug load feed powders, and consequently the manufacturability of high drug load minitablets. 

The paper is available in the PAPERS section.

Conclusions:

• Silicification of the high drug load physical mix feed powders alone did not yield satisfactory quality attributes and compaction parameters to produce good quality minitablets
  
• Granulation of fine paracetamol powder was crucial for the preparation of good quality high drug load minitablets. 
  
• High shear granulation demonstrated greater process robustness than fluid bed granulation, with less discernment on the quality attributes of feed powder.