MySTYL'One
May 26, 2023
The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet.
This review mainly focuses on various dosage forms like Solid, Sem...
The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet.
This review mainly focuses on various dosage forms like Solid, Semisolid, Liquisolid, and Solidified liquid dosage forms. These techniques mainly characterize all substances using 12 parameters, resulting 12-sided regular polygon.
This new paper is available here on MySTYL’One.
MySTYL'One
May 2, 2023
This paper examines the influence of pharmaceutical processing techniques on the properties of high drug load feed powders, and consequently the manufacturability of high drug load minitablets.
The paper is available in the PAPERS section.
Conclusions:
This paper examines the influence of pharmaceutical processing techniques on the properties of high drug load feed powders, and consequently the manufacturability of high drug load minitablets.
The paper is available in the PAPERS section.
Conclusions:
#granulation #silification #minitablet #processing #manufacturability #drug load
Caleva
Jan. 26, 2023
Spheronization (or Marumerization) is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.
#Mixer #coater #lab insturment #granulation #R&D #caleva #extruder #spheronization
Bruno Villa
Sept. 10, 2021
WHY IS DRY GRANULATION SO POPULAR THESE DAYS?
Granulation of pharmaceutical powder is often required to
prevent segregation of the Active Pharmaceutical Ingredient
(API) and/or to enhance the blend flowability, which is critical
to ensure consistent tablet mass (weight) on rotary tablet
presses.
Dry granulation has been known for decades. The main benefit
is a lower cost of operation compared to wet granulation.
But most interestingly, it’s much easier to contain a roller compactor to process high potent drugs. It’s also a truly
continuous process, which is a big trend these days. One have
to point out that in the past decade, equipment manufacturers
have introduced more instrumentation and advanced control
systems, such as Gerteis or LB Bohle to name a few, allowing
a more consistent density on the ribbons through a gap control
loop system