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Showing posts tagged as : #granulation

Press review

MySTYL'One

May 26, 2023

Particle Engineering via QESD crystallization

The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet. 

This review mainly focuses on various dosage forms like Solid, Sem...

The SeDeM diagram expert system (DES) determines the suitability of excipients and active ingredients for Direct Compression and the ratio of API to excipient is calculated. The DC is most suitable as it saves time and makes process easy, but these technique excipients compensate for their poor flow. Thus, a new system was required to help reduce number of experiments and time for making an optimized direct compression tablet. 

This review mainly focuses on various dosage forms like Solid, Semisolid, Liquisolid, and Solidified liquid dosage forms. These techniques mainly characterize all substances using 12 parameters, resulting 12-sided regular polygon.

This new paper is available here on MySTYL’One

#direct compression #metformin hydrocholoride #granulation

Announcement

MySTYL'One

May 2, 2023

Study of diminutive granules as feed powders for manufacturability of high drug load minitablets

This paper examines the influence of pharmaceutical processing techniques on the properties of high drug load feed powders, and consequently the manufacturability of high drug load minitablets. 

The paper is available in the PAPERS section.

Conclusions:

  • Silicification of the high drug load physical mix feed powders alone did not yield satisfactory quality attributes and compaction parameters to produce good quality minitablets
  • Granulation of fine paracetamol powder was crucial for the preparation...

This paper examines the influence of pharmaceutical processing techniques on the properties of high drug load feed powders, and consequently the manufacturability of high drug load minitablets. 

The paper is available in the PAPERS section.

Conclusions:

  • Silicification of the high drug load physical mix feed powders alone did not yield satisfactory quality attributes and compaction parameters to produce good quality minitablets
  • Granulation of fine paracetamol powder was crucial for the preparation of good quality high drug load minitablets. 
  • High shear granulation demonstrated greater process robustness than fluid bed granulation, with less discernment on the quality attributes of feed powder.

#granulation #silification #minitablet #processing #manufacturability #drug load

Feature article

Caleva

Jan. 26, 2023

An introduction to Spheronization (or Marumerization)

Spheronization (or Marumerization) is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 to about 3.0 mm. The use of these spheroids can be relevant for a wide variety of industries.

#Mixer #coater #lab insturment #granulation #R&D #caleva #extruder #spheronization

Feature article

Bruno Villa

Sept. 10, 2021

Dry Granulation a material sparing method

WHY IS DRY GRANULATION SO POPULAR THESE DAYS?

Granulation of pharmaceutical powder is often required to prevent segregation of the Active Pharmaceutical Ingredient (API) and/or to enhance the blend flowability, which is critical to ensure consistent tablet mass (weight) on rotary tablet presses. Dry granulation has been known for decades. The main benefit is a lower cost of operation compared to wet granulation. But most interestingly, it’s much easier to contain a roller compactor to process high potent drugs. It’s also a truly continuous process, which is a big trend these days. One have to point out that in the past decade, equipment manufacturers have introduced more instrumentation and advanced control systems, such as Gerteis or LB Bohle to name a few, allowing a more consistent density on the ribbons through a gap control loop system

#dry #granulation

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