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Showing posts tagged as : #magnesium stearate

Announcement

MySTYL'One

Sept. 19, 2022

Impact of alternative lubricants on process and tablet quality for direct compression


In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The study is available in the PAPERS section.

Find others papers here and learn about

  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • Tablet formulation development focusing on the functional behaviour of water uptake and swelling
  • Mean yield pressure from the in-die Heckel analysis is a reliable plast...

In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The study is available in the PAPERS section.

Find others papers here and learn about

  • Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis Bullosa
  • Tablet formulation development focusing on the functional behaviour of water uptake and swelling
  • Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

#Direct Compression #magnesium stearate #tableting #lubrication #compaction simulator

Feature article

Bruno Leclercq

Sept. 29, 2020

Lubrication now easy-to-use for R&D lab environment

Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.

To specifically solve sticking and flowability issu...

Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the wear of punches and dies and avoid that tablets are stressed and damaged when ejected from the die cavity. Besides decreasing the friction that has often been described as the true role of a lubricant, lubricants can also serve as anti-adherent and glidant.

To specifically solve sticking and flowability issues, other excipients should be used, such as talc and colloidal silicon dioxide, respectively. Lubricants are a key excipient category in solid formulations but they can also lead to loss of tablet breaking force as well as slow down of dissolution. In order to maintain ejections forces as low as possible while minimizing the negative impact on tablet hardness and dissol...

#STYLOne #magnesium stearate #lubrication #MIST

Press review

Biogrund.com

July 10, 2020

Replacing the lubricants stearic acid or magnesium stearate with lubricants based on natural ingredients

Comparison of lubrication

In this study traditionally used lubricants stearic acid & magnesium stearate were replaced with natural based lubricants (rice extract) or excipient premixes (cellulose/rice extract/oil/wax). The ejection force was measured to determine best lubrication. 

#stearic acid #rice extract #ejection force #magnesium stearate #lubrication

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