Pharmaceutical Technology
May 22, 2023
R&D tablet presses are an essential part of the laboratory, providing complete tablet compression functionality from a compact system. Using advanced tableting instrumentation, formulation scientists can perform feasibility experiments that help to improve yields and secure product scale-up later on.
6 things to look for when choosing an R&D tablet press
1. Scalability
Scaling up a tableting process from R&D to production can be challenging, with formulation problems likely to arise in the form of tablet defects. Advanced R&D presses help to prevent issues by mimicking the tablet compression characteristics of high-speed production equipment.
2. Return on investment
The right tablet press should result in significant cost savings for your business. It is important to choose a system with comprehensive data acquisition and analysis software. This can help to evaluate tablet quality and develop more robust formulations, meaning less defects and downtime during production.
3. Versatility
Finding a versatile R&D tablet press is key for flexible drug development. With one compaction simulator, you have access to several production processes in one place. You can simulate all the high-speed production presses or roller compactors on the market, so this means versatility.
4. Ease of use
Tablet compression and powder characterisation technology is inherently complex, but it shouldn’t seem so to users. Most vendors will claim to offer intuitive software, so it’s important to consider what actions were taken during development to ensure this.
5. Operator safety
With pharma’s increasing use of highly potent active pharmaceutical ingredients (HPAPIs), purchasing tablet presses with containment features is becoming more and more critical.
6. Strong Service Network
Every so often, maintenance is recommended to keep your tablet press running smoothly across a long service life. “Reactivity in case of issues is key.” In the time-pressured environment of pharma R&D, slow service from your tablet press partner could set you back in time and money.
#versatility #scale-up #compaction simulation #'tablet press' #operator safety
Korsch AG
May 15, 2023
There is a wide portfolio of tablet presses on the market. The press design is depending on the application area. While in R&D only small quantities of powder formulations are available, high throughputs must be generated in the production area. It is a challenging task to assess the critical quality attributes for large scale productions already during the formulation development stage. Even though academia and industry are investigating and implementing scale-up of tablet production sin...
There is a wide portfolio of tablet presses on the market. The press design is depending on the application area. While in R&D only small quantities of powder formulations are available, high throughputs must be generated in the production area. It is a challenging task to assess the critical quality attributes for large scale productions already during the formulation development stage. Even though academia and industry are investigating and implementing scale-up of tablet production since decades, no consensus is found on how to do it best. This is due to the wide variety of formulations which are compressed. Also, the final tablet shapes and sizes do differ tremendously. From mini tablets in low volume to standard tablets in high-volume, a wide range must be covered depending on the application.
Medelpharm
Jan. 18, 2023
MySTYL'One members exclusive!
can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have...
MySTYL'One members exclusive!
can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have speed limits! Speed sensitivity may also be called strain rate sensitivity. The penalty for exceeding the speed limit is capping, making tablet production impossible. During development capping/lamination is unacceptable for further progression.
#viscoelasticity #tablet development #scale-up #Quality by Design #capping
CPhI Global Pharma Events
July 9, 2022
MySTYL'One members exclusive!
CPhI worldwide 2018
Conference in the ICSE theatre : Compression Simulation as a Powerful Quality by Design (QbD) Tool
Animated by Aline Moulin, Senior Project Manager - Pharmaceutical Development
#STYL'One evo #scale-up #optimization #QbD #compaction simulator #conference #prototype
pharmaceutical-technology
April 1, 2022
Let's discover MEDELPHARM, a campany specialized in solutions for drug development process for solid dose pharmaceutical product. All processes are concerned, including "extensive formulation development, preclinical testing and clinical trials..."
Click here for full article.
MySTYL'One
Jan. 9, 2022
The paper highlights an evaluation method to determine the effect of speed during tableting on the compression properties of pharmaceutical powders (APIs mixed with excipients).
Different tests were conducted to determine viscoelasticity, stress relaxation, followed by compaction on both STYL’One compaction simulator and a rotary press. Results show that the sensitivity of the out-of-die SRS was higher than that of in-die SRS.
Full results available in the paper, head to
the “Papers” section of...
The paper highlights an evaluation method to determine the effect of speed during tableting on the compression properties of pharmaceutical powders (APIs mixed with excipients).
Different tests were conducted to determine viscoelasticity, stress relaxation, followed by compaction on both STYL’One compaction simulator and a rotary press. Results show that the sensitivity of the out-of-die SRS was higher than that of in-die SRS.
Full results available in the paper, head to
the “Papers” section of MySTYL'One (members only).
#scale-up #viscoelasticity #'strain rate sensitivity' #'tableting speed' #'out-of-die' #'compression'
MySTYL'One
Dec. 1, 2021
Article published on Pharmaceutical Online that reviews selecting this specific dosage form, manufacturing challenges and how to
overcome them, considerations for evaluating a CDMO, and the typical timeframe
for scale-up.
Access the news HERE.