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Keep up with the latest in the tableting community!


Showing posts tagged as : #scale-up

Feature article

Medelpharm

Jan. 18, 2023

Tableting Rheology and Quality by Design

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have...

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have speed limits! Speed sensitivity may also be called strain rate sensitivity. The penalty for exceeding the speed limit is capping, making tablet production impossible. During development capping/lamination is unacceptable for further progression.

#viscoelasticity #tablet development #scale-up #Quality by Design #capping

Video

CPhI Global Pharma Events

July 9, 2022

Flashback on Skyepharma conference on Compaction simulation at CPhI worldwide edition 2018

MySTYL'One members exclusive!

CPhI worldwide 2018

Conference in the ICSE theatre : Compression Simulation as a Powerful Quality by Design (QbD) Tool

Animated by Aline Moulin, Senior Project Manager - Pharmaceutical Development

#STYL'One evo #scale-up #optimization #QbD #compaction simulator #conference #prototype

Press review

pharmaceutical-technology

April 1, 2022

Meet the company on a mission to revolutionise tableting scale-up

Let's discover MEDELPHARM, a campany specialized in solutions for drug development process for solid dose pharmaceutical product. All processes are concerned, including "extensive formulation development, preclinical testing and clinical trials..."

Click here for full article.

#STYL'One Nano #scale-up #Medelpharm #development

Press review

MySTYL'One

Jan. 9, 2022

Characterization of tableting speed-dependent deformation properties of active pharmaceutical ingredients in powder mixtures using out-of-die method

The paper highlights an evaluation method to determine the effect of speed during tableting on the compression properties of pharmaceutical powders (APIs mixed with excipients).

Different tests were conducted to determine viscoelasticity, stress relaxation, followed by compaction on both STYL’One compaction simulator and a rotary press. Results show that the sensitivity of the out-of-die SRS was higher than that of in-die SRS.


Full results available in the paper, head to the “Papers” section of...

The paper highlights an evaluation method to determine the effect of speed during tableting on the compression properties of pharmaceutical powders (APIs mixed with excipients).

Different tests were conducted to determine viscoelasticity, stress relaxation, followed by compaction on both STYL’One compaction simulator and a rotary press. Results show that the sensitivity of the out-of-die SRS was higher than that of in-die SRS.


Full results available in the paper, head to the “Papers” section of MySTYL'One (members only).

#scale-up #viscoelasticity #'strain rate sensitivity' #'tableting speed' #'out-of-die' #'compression'

Press review

MySTYL'One

Dec. 1, 2021

Exploring bilayer tablet manufacturing

Article published on Pharmaceutical Online that reviews selecting this specific dosage form, manufacturing challenges and how to overcome them, considerations for evaluating a CDMO, and the typical timeframe for scale-up.
Access the news HERE

#multilayer #Q&A #scale-up #bilayer

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