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Showing posts tagged as : #tablet

Announcement

MySTYL'One

Sept. 22, 2022

The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation


In this paper, the information on excipients physical and chemical instability and compatibility with the active pharmaceutical component in solid oral dosage forms during various drug manufacturing procedures is reviewed. The study is available in the PAPERS section.

Find others papers here and learn about

  • A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants
  • Development of an Automated Microscale Manufacturing System for Oral Solid Dosage For...

In this paper, the information on excipients physical and chemical instability and compatibility with the active pharmaceutical component in solid oral dosage forms during various drug manufacturing procedures is reviewed. The study is available in the PAPERS section.

Find others papers here and learn about

  • A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants
  • Development of an Automated Microscale Manufacturing System for Oral Solid Dosage Forms
  • A generalized image analytical algorithm for investigating tablet disintegration

#oral solid dosage forms #pills #excipients #capsules #tablet #powder

Feature article

pharmaceutical-technology

July 25, 2022

How to mitigate risks in process scale-up ?

On this article you will find how pharmaceutical companies can improve the efficiency of their entire product development and drug commercialisation process with the ever-rising costs of bringing a drug to market. A well-known source of bottlenecks, delays, and technical setbacks is process scale-up, where production moves from the laboratory to full-scale GMP manufacturing

#multilayer #manufacture #tablet #containment #HPAPI

Announcement

MySTYL'One

July 22, 2022

On the complexity of predicting tablet capping


The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.

Find others papers here and learn about

  • Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
  • Enabling ...

The present works demonstrated from a study to predict capping on biconvex tablets from a wide range of products (18 formulations, 8 of which presenting capping), using the properties characterized on defect-free flat-faced tablets (tensile strength, solid fraction, elastic recovery, etc.). The study is available in the PAPERS section.

Find others papers here and learn about

  • Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets
  • Enabling the direct compression of metformin hydrochloride through QESD crystallization
  • Role of Precompression in the Mitigation of Capping: A Case Study

#STYL'One evo #tablet #compaction #decision tree #capping

Feature article

pharmaceutical-technology

July 20, 2022

Pharmaceutical Technology - Top trends in tablet manufacturing

Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance pat...

Tablets are by far the most widely used pharmaceutical dosage form, followed by capsules. Tablets are cost-effective, stable, and easy-to-administer. The main advantage is that compression allows for high speed manufacturing with a very high level of quality control. As such, tablets have been popular among pharmacists since the emergence of the tablet compression industry in the mid-20th century. Despite this long history, the industry is continually improving this dosage form to advance patient care. Meanwhile, the processes and equipment it uses to manufacture these products are also advancing.

#multilayer #manufacture #tablet #containment #HPAPI

Announcement

MySTYL'One

June 20, 2022

Impact of unloading kinematics on the occurrence of capping during the production of pharmaceutical tablets


The present work details the influence of the unloading step on capping using a compaction simulator. Full paper available in the PAPERS section.

Find others papers here and learn about

  • Studying the impact of lubrication on tablet properties using STYL'One
  • The effect of spray drying on the compaction properties of hypromellose acetate succinate

#tableting #capping #compression #STYLOne #tablet #Defects

Feature article

MySTYL'One

June 15, 2022

Webinar: "Fundamental Investigations on bilayer tablets"

- The event is now over - Stay tuned for additional info soon

June  28th, 3 pm (Paris Time)

"Fundamental investigations on bilayer tablets - Effects of process parameters and geometry on interfacial strength"

#multilayer #tablet #interfacial adhesion #delamination #tablet geometry

Press review

MySTYL'One

Jan. 4, 2022

Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt Granulation of Metformin Hydrochloride

The purpose of this new study was to evaluate the processability and dissolution behavior of HPC GXF ((Klucel® GXF) and a recently introduced type of hot-melt extrudable HPMC (Affinisol®) in extended-release metformin hydrochloride formulations using twin-screw melt granulation. The powder blends were then granulated at different temperatures, then tableted. Rheological studies (steady steer rate viscosity and rotation rheometry) as well as dissolution studies were then performed. Full paper ...

The purpose of this new study was to evaluate the processability and dissolution behavior of HPC GXF ((Klucel® GXF) and a recently introduced type of hot-melt extrudable HPMC (Affinisol®) in extended-release metformin hydrochloride formulations using twin-screw melt granulation. The powder blends were then granulated at different temperatures, then tableted. Rheological studies (steady steer rate viscosity and rotation rheometry) as well as dissolution studies were then performed. Full paper available in the PAPERS section.

#polymer #hydroxypropyl methylcellulose #melt extrusion #hydroxypropyl cellulose #rheology #twin screw melt granulation #binder #tablet

Announcement

MySTYL'One

July 13, 2021

The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods

This new study from the University of Braunschweig explores the microstructure of tablets, analyzable thanks to X-ray microtomgraphy (XMT). 

This helps to get a deeper understanding of their properties: mechanical strength, component distribution etc. XMT measurements are then compared with other methods used to characterize APIs. Access the paper HERE

#pore size distribution #API homogeneity #Micro-cracks #tablet microstructure #tablet #X-ray microtomography

Feature article

MEDELPHARM

May 3, 2021

Troubleshooting tablet defects in no-time

There are numerous tablet defects: chipping, picking & sticking, cracking, lamination & capping to name a few.

Lamination & capping often occur during scale-up and are main issues in our industry. Capping is the partial or complete removal of the crown of a tablet from the main body, while lamination is the separation of a tablet into two or more distinct layers. However, those 2 phenomenon share similar causes...

#troubleshooting #deffect #tablet

Press review

www.manufacturingchemist.com

Nov. 24, 2020

First impressions: Tablet shape can impact patient acceptance

One new interesting article we've discovered on manufacturingchemist.com, dealing with tablet design and its impact on patient acceptance.

What would be the benefits of a flat faced radius edge tablet design as compared to a flat faced bevel edge?

Full article is online here



#tablet #Design principles

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