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Showing posts tagged as : #tablet development

Feature article

Medelpharm

Jan. 18, 2023

Tableting Rheology and Quality by Design

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have...

MySTYL'One members exclusive!

Quality by Design (QbD) in tablet development

can be challenging, due to the multiple competing technological aims, such as flow, compactability, lubrication and drug release. Tablets are complex and, whether due to ignorance or indeterminacy, uncertainty also makes it difficult to develop tablets robust enough to cope with scale-up and Production. Speed sensitivity of the compression mix can come as an unwelcome surprise to those who did not know that tablets have speed limits! Speed sensitivity may also be called strain rate sensitivity. The penalty for exceeding the speed limit is capping, making tablet production impossible. During development capping/lamination is unacceptable for further progression.

#viscoelasticity #tablet development #scale-up #Quality by Design #capping

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