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Discover scientific papers, case studies and tutorials dedicated to compression...


Dosage Form Design and Patient Compliance: Exploring Orally Disintegrating Tablets as a Patient-Centric Solution

Poor compliance with a medication regimen reduces treatment effectiveness for the patient and has a significant impact on overall healthcare costs. Some of the common factors influencing compliance are the disease being treated, patient age and the therapy regimen itself. Therefore, when developing dosage forms, it is important to consider specific patient challenges for different diseases. This article explores the needs of different patient groups, identifies frequent issues leading to non-compliance, looks at the role of orally disintegrating tablets (ODTs) in helping improve patient compliance and provides examples of improving the delivery profile of the drug.

Direct Compression of Probiotic Tablets with PROSOLV® EASYtab Nutra

Although probiotics are mostly administered in the form of capsules, there are some advantages of tablets in terms of production effort, cost efficiency and stability of the probiotic bacteria. As probiotics are sensitive to high pressure and temperature, it is essential to select appropriate excipients for direct compression to ensure sufficient viability of the bacteria cells during production and storage. The aim of this study was to investigate the performance of the high functional excipient PROSOLV® EASYtab Nutra for direct compression of probiotic tablets. As PROSOLV® EASYtab Nutra is an all-in-one composite, only one mixing step is required before the compaction which makes the tableting process easy and comfortable. In order to evaluate the performance of PROSOLV® EASYtab Nutra, the survival rate of the bacteria and functional tablet properties were determined and compared to a lactose-based formulation. The study showed that PROSOLV® EASYtab Nutra is considerably better suited for direct compression of probiotic tablets because of the remarkable survival rate of 91.5 % of the bacteria cells as well as the quick disintegration within 18 seconds, which is almost 10 times faster compared to the lactose formulation. Furthermore PROSOLV® EASYtab Nutra is characterized by excellent compactability and an extremely low friability.

The performance of PROSOLV EASYtab SP in Four Medium-Dose, Direct Compression Formulations with Morphologically Challenging Model APIs

In the present study, the performance of PROSOLV EASYtab SP was tested in four DC formulations with different model APIs. Each of selected APIs presented a particular challenge in terms of producing tablets with suitable hardness, weight uniformity, content uniformity and/or reliable dissolution profiles. PROSOLV EASYtab SP was shown to perform considerably better than the corresponding physical mixture of its components for all formulations tested.

API
Direct Compression
PROSOLV
dry blends
excipient composite

Effect of precompression on capping tendency

Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects. It means that formulation scientists or tech transfer engineers can assess the influence of process parameters on tablet properties to preempt risk during scale-up or to solve production issues with minimal powder consumption and avoiding unnecessary use of production assets. 

The goal of this bulletin is to generate tablet defects such as capping and use precompression to lessen this phenomenon without modifying the formulation. This will demonstrate that such tablet defects can be foreseen on compaction simulators right from the development stage to reduce cost and save time during scale-up and production. 

STYL'One Nano
capping
process parameters
tablet defect
tablet properties

A fundamental step in your tablet development

Formulation development and technical transfer from lab to production can be challenging and requires a deep knowledge of your formulation. The integrated and intuitive data analysis features drive formulators and scientists in their decision-making process with build-in graphs and reports to develop robust and scalable formulations. Knowledge management based on data leads to avoid tablet defects in production and guarantee high production output. This can be undertaken right from the development stage thanks to STYL’One compaction simulators

Capping
Formulation optimization
Lamination
Tablet development
Tabletability assessment

Radial die wall pressure measurement

Instrumented die is used to measure maximum die-wall pressure (MDP) and residual die-wall pressure (RDP) during powder compaction. This document aims to provide a methodology to characterize powders with this device.

STYL'One Evo
die-wall
instrumented die
radial pressure

Advantages of Mannitol in Pharmaceutical Granulation Processes - A Comparison of Different Polymorphic Forms

Success of a wet granulation process depends on selection of appropriate excipients and choice of suitable process parameters which lead to excellent binding and compaction properties and flow.

This bulletin presents how standard crystallized mannitol in β-polymorphic form often lacks sufficient binding and tableting properties for use with wet granulation

Mannitol
binding
tableting
wet granulation

Assess the impact of your granulation process parameters with the STYL'One Evo

Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new directcompression grade of excipient produced by granulation.

This bulletin presents the methodology of MEDELPHARM Science Lab to study the effects of granulation critical process parameters on product quality attributes.

STYL'One Evo
angle of repose
carr index
compactibility
flowability
powder granulation
pressure

Material Characterization with a V-shape compression profile on STYL'One Nano

In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet quality such as its hardness depends on several process parameters including the compression speed, pressure and profile used.

Compaction simulators, such as the STYL’One Nano, can easily explore compression dynamics and allow researchers to deeply understand their powder with only few grams of material. This avant-garde technology is key for fundamental material characterization and deep understanding of their product.

The goal of this bulletin is to dive into the V-shape compression cycle available on STYL’One Nano and to demonstrate its usefulness in powder characterization with real speed sensitivity practical examples.

Material Science
STYL'One Nano
V-shape compression cycle
compaction parameters
compression profile
material characterization
speed sensitivity

Material Characterization with Extended Dwell Time Compression Profile on STYL'One Nano

During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design the best formulation possible and find suitable process parameters for production.

Compaction simulators, such as the STYL’One Nano, can easily explore compression dynamics and allow researchers to deeply understand their powder with only few grams of material. This premium technology is key for fundamental material characterization and deep understanding of your powder.

The goal of this bulletin is to dive into the Extended Dwell Time cycle available on STYL’One Nano and to demonstrate its usefulness in powder characterization with real practical examples.


Dwell time
Process parameters
STYL'One Nano
compression profile
deformation behavior

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